Catalina LEE-CHANG is an immunologist, with a strong background in B-cell immunology. She obtained her PhD in Pr. L PRIN’s lab (EA2686, Lille, France) where she studied the place of B-cell-mediated immune response in chronic inflammatory disease such as multiple sclerosis (MS).
She joined the NIH (Baltimore, MD, USA) as postdoctoral trainee to study the role of cellular B-cell immunity in cancer escape and metastasis in Dr. A. Biragyn's Lab. She contributed to the characterization of tumor-evoked regulatory B cells (tBregs) and studied the therapeutic relevance of inhibiting tBregs to successfully fight cancer escape. In addition, she dedicated major part of her research to understand how aging affects B-cell functional plasticity. Among her contribution to the aging immunology field, it is underlined the discovery of a novel pro-inflammatory B-cell subset expressing the costimulatory marker 4-1BBL that strongly control the anti-tumor immunity.
She then pursued her scientific career as Research Associate at the Neuroinflammation/MS Team (UMR995, Lille, France) led by Dr. Lennart MARS. Her scientific interest laid on the study of the pathogenicity of the cellular B cell response in chronic inflammation.
Her current work in Dr. Lesniak's lab focuses on the potential role of cellular B cells in supporting brain tumor.
For a full list of publications, please see www.ncbi.nlm.nih.gov/pubmed/?term=lee+chang+c.